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KMID : 0043320160390101382
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Archives of Pharmacal Research
2016 Volume.39 No. 10 p.1382 ~ p.1390
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Novel hybrids of drug with bioactive heterocycles for enhancing biological activity
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Valentina Parthiban
Ilango Kaliappan
Kathiravan Muthu K.
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Abstract
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A novel series of aceclofenac hybridised with 1,2,4-triazolo-[3,4-b]-1,3,4-thiadiazoles were designed using molecular hybridization approach and synthesised 6a?j. The structural integrity was confirmed by analytical methods. The hybrid molecules were subjected to in vitro cytotoxic studies against four human cancer cell lines PA?1, OAW?42, T47-D and MCF?7 by MTT assay method. The results indicate that the hybrid molecules bearing halogen on phenyl ring in 6th position of triazolo-thiadiazole exhibited significant cytotoxic activity. The test compounds were also screened for antifungal activity against two strains.
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KEYWORD
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Triazolo-thiadiazole, Cytotoxic, Molecular hybrids
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